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Overcoming drug resistance through the development of selective inhibitors of UDP-glucuronosyltransferase enzymes
Drug resistance is a major cause of cancer-related mortality. Glucuronidation of drugs via elevation of UDP-glucuronosyltransferases (UGT1As) correlates with clinical resistance. The nine UGT1A family members have broad substrate specificities attributed to their variable N-terminal domains and shar...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6331242/ https://ncbi.nlm.nih.gov/pubmed/30428301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.11.007 |
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