Overcoming drug resistance through the development of selective inhibitors of UDP-glucuronosyltransferase enzymes

Drug resistance is a major cause of cancer-related mortality. Glucuronidation of drugs via elevation of UDP-glucuronosyltransferases (UGT1As) correlates with clinical resistance. The nine UGT1A family members have broad substrate specificities attributed to their variable N-terminal domains and shar...

Full description

Saved in:
Bibliographic Details
Published in:J Mol Biol
Main Authors: Osborne, Michael J., Coutinho de Oliveira, Luciana, Volpon, Laurent, Zahreddine, Hiba Ahmad, Borden, Katherine L.B.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331242/
https://ncbi.nlm.nih.gov/pubmed/30428301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.11.007
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items