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Experimental approach to study the effect of mutations on the protein folding pathway

Is it possible to compare the physicochemical properties of a wild-type protein and its mutant form under the same conditions? Provided the mutation has destabilized the protein, it may be more correct to compare the mutant protein under native conditions to the wild-type protein destabilized with a...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Nemtseva, Elena V., Gerasimova, Marina A., Melnik, Tatiana N., Melnik, Bogdan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331109/
https://ncbi.nlm.nih.gov/pubmed/30640946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210361
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