Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells

Mismatch repair (MMR)-deficient or microsatellite instability (MSI) colorectal cancer includes two subtypes; Lynch syndrome and sporadic MSI cancer, both of which generate multiple neoantigens due to unrepaired mutations. Although such patients respond very well to immune checkpoint therapy, their d...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Yamaura, Tadayoshi, Miyoshi, Hiroyuki, Maekawa, Hisatsugu, Morimoto, Tomonori, Yamamoto, Takehito, Kakizaki, Fumihiko, Higasa, Koichiro, Kawada, Kenji, Matsuda, Fumihiko, Sakai, Yoshiharu, Taketo, M. Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331025/
https://ncbi.nlm.nih.gov/pubmed/30680068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26495
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