Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

BACKGROUND: Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified. METHODS: Using a novel enzyme-linked i...

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Detalhes bibliográficos
Publicado no:Thromb J
Main Authors: Yokoyama, Yayoi, Ito, Takashi, Yasuda, Tomotsugu, Furubeppu, Hiroaki, Kamikokuryo, Chinatsu, Yamada, Shingo, Maruyama, Ikuro, Kakihana, Yasuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330748/
https://ncbi.nlm.nih.gov/pubmed/30651722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12959-018-0190-4
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