Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin

BACKGROUND: Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress. rTM mainly exerts its anticoagulant effects through an activated protein C (A...

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Detalhes bibliográficos
Publicado no:Thromb J
Main Authors: Arishima, Takuro, Ito, Takashi, Yasuda, Tomotsugu, Yashima, Nozomi, Furubeppu, Hiroaki, Kamikokuryo, Chinatsu, Futatsuki, Takahiro, Madokoro, Yutaro, Miyamoto, Shotaro, Eguchi, Tomohiro, Haraura, Hiroyuki, Maruyama, Ikuro, Kakihana, Yasuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161343/
https://ncbi.nlm.nih.gov/pubmed/30275773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12959-018-0178-0
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