Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3

BACKGROUND: Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified. METHODS: We developed a novel enzyme-linked immunosorbent assay (ELISA) for detection of circulati...

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Detalhes bibliográficos
Publicado no:J Intensive Care
Main Authors: Ito, Takashi, Nakahara, Mayumi, Masuda, Yoshiki, Ono, Sachie, Yamada, Shingo, Ishikura, Hiroyasu, Imaizumi, Hitoshi, Kamikokuryo, Chinatsu, Kakihana, Yasuyuki, Maruyama, Ikuro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260889/
https://ncbi.nlm.nih.gov/pubmed/30505450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40560-018-0348-y
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