Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

INTRODUCTION: Recent studies have shown that histones, the chief protein component of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and act as major mediators of the death of an organism. This study was designed to elucidate the cellular...

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Detalhes bibliográficos
Main Authors: Nakahara, Mayumi, Ito, Takashi, Kawahara, Ko-ichi, Yamamoto, Mika, Nagasato, Tomoka, Shrestha, Binita, Yamada, Shingo, Miyauchi, Takahiro, Higuchi, Koji, Takenaka, Toshihiro, Yasuda, Tomotsugu, Matsunaga, Akira, Kakihana, Yasuyuki, Hashiguchi, Teruto, Kanmura, Yuichi, Maruyama, Ikuro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786915/
https://ncbi.nlm.nih.gov/pubmed/24098750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075961
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