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Recombinant thrombomodulin alleviates oxidative stress without compromising host resistance to infection in rats infected with methicillin-resistant Staphylococcus aureus

Recombinant thrombomodulin (rTM) has been used for treatment of sepsis-associated disseminated intravascular coagulation. Recent studies have suggested that anticoagulant therapy might dampen the protective role of immunothrombosis. We examined if rTM might worsen infectious diseases. Male Sprague–D...

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Publicat a:Sci Rep
Autors principals: Ito, Takashi, Shrestha, Binita, Kakihana, Yasuyuki, Maruyama, Ikuro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566838/
https://ncbi.nlm.nih.gov/pubmed/33060764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74529-4
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