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Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates

Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via cerebromedullary cistern, lumbar, cerebromedullar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Ohno, Kousaku, Samaranch, Lluis, Hadaczek, Piotr, Bringas, John R., Allen, Philip C., Sudhakar, Vivek, Stockinger, Diane E., Snieckus, Christopher, Campagna, Michael V., San Sebastian, Waldy, Naidoo, Jerusha, Chen, Haifeng, Forsayeth, John, Salegio, Ernesto A., Hwa, Granger G.C., Bankiewicz, Krystof S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330508/
https://ncbi.nlm.nih.gov/pubmed/30666308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.12.001
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