Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties

We present an approach to assess antibody CDR-H3 loops according to their dynamic properties using molecular dynamics simulations. We selected six antibodies in three pairs differing substantially in their individual promiscuity respectively specificity. For two pairs of antibodies crystal structure...

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發表在:Front Immunol
Main Authors: Fernández-Quintero, Monica L., Loeffler, Johannes R., Kraml, Johannes, Kahler, Ursula, Kamenik, Anna S., Liedl, Klaus R.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330313/
https://ncbi.nlm.nih.gov/pubmed/30666252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03065
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