LAMP-2B regulates human cardiomyocyte function by mediating autophagosome–lysosome fusion

Mutations in lysosomal-associated membrane protein 2 (LAMP-2) gene are associated with Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined mechanisms. Here, we identify the LAMP-2 isoform B (LAMP-2B) as required for autophagosome–lysosome fusion in human cardiomyo...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chi, Congwu, Leonard, Andrea, Knight, Walter E., Beussman, Kevin M., Zhao, Yuanbiao, Cao, Yingqiong, Londono, Pilar, Aune, Ellis, Trembley, Michael A., Small, Eric M., Jeong, Mark Y., Walker, Lori A., Xu, Hongyan, Sniadecki, Nathan J., Taylor, Matthew R., Buttrick, Peter M., Song, Kunhua
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329949/
https://ncbi.nlm.nih.gov/pubmed/30584088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808618116
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