LAMP-2B regulates human cardiomyocyte function by mediating autophagosome–lysosome fusion

Mutations in lysosomal-associated membrane protein 2 (LAMP-2) gene are associated with Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined mechanisms. Here, we identify the LAMP-2 isoform B (LAMP-2B) as required for autophagosome–lysosome fusion in human cardiomyo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chi, Congwu, Leonard, Andrea, Knight, Walter E., Beussman, Kevin M., Zhao, Yuanbiao, Cao, Yingqiong, Londono, Pilar, Aune, Ellis, Trembley, Michael A., Small, Eric M., Jeong, Mark Y., Walker, Lori A., Xu, Hongyan, Sniadecki, Nathan J., Taylor, Matthew R., Buttrick, Peter M., Song, Kunhua
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329949/
https://ncbi.nlm.nih.gov/pubmed/30584088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808618116
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