LAMP-2B regulates human cardiomyocyte function by mediating autophagosome–lysosome fusion

Mutations in lysosomal-associated membrane protein 2 (LAMP-2) gene are associated with Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined mechanisms. Here, we identify the LAMP-2 isoform B (LAMP-2B) as required for autophagosome–lysosome fusion in human cardiomyo...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Chi, Congwu, Leonard, Andrea, Knight, Walter E., Beussman, Kevin M., Zhao, Yuanbiao, Cao, Yingqiong, Londono, Pilar, Aune, Ellis, Trembley, Michael A., Small, Eric M., Jeong, Mark Y., Walker, Lori A., Xu, Hongyan, Sniadecki, Nathan J., Taylor, Matthew R., Buttrick, Peter M., Song, Kunhua
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329949/
https://ncbi.nlm.nih.gov/pubmed/30584088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808618116
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