Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei

In Trypanosoma brucei, most mitochondrial mRNAs undergo editing, and 3′ adenylation and uridylation. The internal sequence changes and terminal extensions are coordinated: pre-editing addition of the short (A) tail protects the edited transcript against 3′-5′ degradation, while post-editing A/U-tail...

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Udgivet i:Nat Commun
Main Authors: Mesitov, Mikhail V., Yu, Tian, Suematsu, Takuma, Sement, Francois M., Zhang, Liye, Yu, Clinton, Huang, Lan, Aphasizheva, Inna
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329795/
https://ncbi.nlm.nih.gov/pubmed/30635574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08137-2
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