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Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues

Cellular senescence refers to an irreversible growth arrest that is triggered by various intrinsic and extrinsic stresses. Many recent studies have demonstrated that cellular senescence plays a crucial role in the regression of tumors exposed to ionizing radiation (IR), but the underlying mechanism...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Jung, Seung Hee, Lee, Minyoung, Park, Hyun A, Lee, Hyung Chul, Kang, Donghee, Hwang, Hyun Jung, Park, Chanho, Yu, Dong-Min, Jung, Yu Ri, Hong, Mi-Na, Kim, Yong-Nyun, Park, Heon Joo, Ko, Young-Gyu, Lee, Jae-Seon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329762/
https://ncbi.nlm.nih.gov/pubmed/29786073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0114-7
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