Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues

Cellular senescence refers to an irreversible growth arrest that is triggered by various intrinsic and extrinsic stresses. Many recent studies have demonstrated that cellular senescence plays a crucial role in the regression of tumors exposed to ionizing radiation (IR), but the underlying mechanism...

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Vydáno v:Cell Death Differ
Hlavní autoři: Jung, Seung Hee, Lee, Minyoung, Park, Hyun A, Lee, Hyung Chul, Kang, Donghee, Hwang, Hyun Jung, Park, Chanho, Yu, Dong-Min, Jung, Yu Ri, Hong, Mi-Na, Kim, Yong-Nyun, Park, Heon Joo, Ko, Young-Gyu, Lee, Jae-Seon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329762/
https://ncbi.nlm.nih.gov/pubmed/29786073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0114-7
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