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mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
Loss of PTEN, the major negative regulator of the PI3K/AKT pathway induces a cellular senescence as a failsafe mechanism to defend against tumorigenesis, which is called PTEN-loss-induced cellular senescence (PICS). Although many studies have indicated that the mTOR pathway plays a critical role in...
שמור ב:
| הוצא לאור ב: | Oncogene |
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| Main Authors: | , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6755978/ https://ncbi.nlm.nih.gov/pubmed/30337688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0521-8 |
| תגים: |
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