mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

Loss of PTEN, the major negative regulator of the PI3K/AKT pathway induces a cellular senescence as a failsafe mechanism to defend against tumorigenesis, which is called PTEN-loss-induced cellular senescence (PICS). Although many studies have indicated that the mTOR pathway plays a critical role in...

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Veröffentlicht in:Oncogene
Hauptverfasser: Jung, Seung Hee, Hwang, Hyun Jung, Kang, Donghee, Park, Hyun A., Lee, Hyung Chul, Jeong, Daecheol, Lee, Keunwook, Park, Heon Joo, Ko, Young-Gyu, Lee, Jae-Seon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755978/
https://ncbi.nlm.nih.gov/pubmed/30337688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0521-8
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