Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A‐catalysed hydroxylation by sulfaphenazole

BACKGROUND AND PURPOSE: The aim of this study was to characterize the human cytochrome P450s (CYPs) involved in oxidative bioactivation of flucloxacillin to 5‐hydroxymethyl flucloxacillin, a metabolite with high cytotoxicity towards biliary epithelial cells. EXPERIMENTAL APPROACH: The CYPs involved...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Dekker, Stefan J, Dohmen, Floor, Vermeulen, Nico P E, Commandeur, Jan N M
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329626/
https://ncbi.nlm.nih.gov/pubmed/30447161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14548
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