Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation

The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, drugs targeting CXCR3 and other chemokine receptors are largely ineffective in treating inflammation. Chemokines, the endogenous peptide ligands of chemokine...

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Udgivet i:Sci Signal
Main Authors: Smith, Jeffrey S., Nicholson, Lowell T., Suwanpradid, Jutamas, Glenn, Rachel A., Knape, Nicole M., Alagesan, Priya, Gundry, Jaimee N., Wehrman, Thomas S., Reck Atwater, Amber, Gunn, Michael D., MacLeod, Amanda S., Rajagopal, Sudarshan
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329291/
https://ncbi.nlm.nih.gov/pubmed/30401786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaq1075
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