Minimal functional driver gene heterogeneity among untreated metastases

Metastases are responsible for the majority of cancer-related deaths. While genomic heterogeneity within primary tumors is associated with relapse, heterogeneity among treatment-naïve metastases has not been comprehensively assessed. We analyzed sequencing data for 76 untreated metastases from 20 pa...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Reiter, Johannes G., Makohon-Moore, Alvin P., Gerold, Jeffrey M., Heyde, Alexander, Attiyeh, Marc A., Kohutek, Zachary A., Tokheim, Collin J., Brown, Alexia, DeBlasio, Rayne M., Niyazov, Juliana, Zucker, Amanda, Karchin, Rachel, Kinzler, Kenneth W., Iacobuzio-Donahue, Christine A., Vogelstein, Bert, Nowak, Martin A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329287/
https://ncbi.nlm.nih.gov/pubmed/30190408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat7171
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