Precancerous neoplastic cells can move through the pancreatic ductal system

Most adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. We analyzed the somatic variants of co-existing pancreatic cancers and precursor lesions sampled from distinct regions of the same pancreas. After inferring evolutionary relationshi...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Makohon-Moore, Alvin P., Matsukuma, Karen, Zhang, Ming, Reiter, Johannes G, Gerold, Jeffrey M, Jiao, Yuchen, Sikkema, Lisa, Attiyeh, Marc, Yachida, Shinichi, Sandone, Cory, Hruban, Ralph H., Klimstra, David S., Papadopoulos, Nickolas, Nowak, Martin A., Kinzler, Kenneth, Vogelstein, Bert, Iacobuzio-Donahue, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342205/
https://ncbi.nlm.nih.gov/pubmed/30177826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0481-8
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