Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis

BACKGROUND: Spondyloarthritis (SpA) is chronic inflammatory arthritis, and interleukin (IL)-17 is crucial in SpA pathogenesis. Type 17 helper T (Th17) cells are one of major IL-17-secreting cells. Signal transducer and activator of transcription (STAT)-3 signaling induces Th17 differentiation. This...

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Bibliographische Detailangaben
Veröffentlicht in:J Transl Med
Hauptverfasser: Min, Hong-Ki, Choi, JeongWon, Lee, Seon-Yeong, Seo, Hyeon-Beom, Jung, KyungAh, Na, Hyun Sik, Ryu, Jun-Geol, Kwok, Seung-Ki, Cho, Mi-La, Park, Sung-Hwan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329133/
https://ncbi.nlm.nih.gov/pubmed/30630513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1774-x
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