Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception

Aggressive breast cancer subtypes utilize system x(c)(−), a membrane antiporter, to import cystine for glutathione synthesis and maintenance of redox homeostasis, in turn releasing glutamate as a metabolic pro-nociceptive by-product. Metastatic breast cancers establish themselves at distal sites inc...

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Veröffentlicht in:Mol Pain
Hauptverfasser: Linher-Melville, Katja, Sharma, Manu, Nakhla, Peter, Kum, Elena, Ungard, Robert, Park, Ji, Rosa, David, Gunning, Patrick, Singh, Gurmit
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329039/
https://ncbi.nlm.nih.gov/pubmed/30799695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806918823477
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