Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity

Pharmacologically targeting activated STAT3 and/or STAT5 has been an active area of cancer research. The cystine/glutamate antiporter, system x(c)(-), contributes to redox balance and export of intracellularly produced glutamate in response to up-regulated glutaminolysis in cancer cells. We have pre...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Linher-Melville, Katja, Nashed, Mina G., Ungard, Robert G., Haftchenary, Sina, Rosa, David A., Gunning, Patrick T., Singh, Gurmit
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981357/
https://ncbi.nlm.nih.gov/pubmed/27513743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161202
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