Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D

Acidosis is a significant feature of the tumor microenvironment in glioma, and it is closely related to multiple biological functions of cancer stem cells. Here, we found that the self-renewal ability, the mitochondrial activity and ATP production were elevated in stem cell-like glioma cells (SLCs)...

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Pubblicato in:Cell Death Dis
Autori principali: Hu, Peishan, Li, Shanshan, Tian, Ningyu, Wu, Fan, Hu, Yan, Li, Dengke, Qi, Yingjiao, Wei, Zhizhong, Wei, Qunfang, Li, Yanchao, Yin, Bin, Jiang, Tao, Yuan, Jiangang, Qiang, Boqin, Han, Wei, Peng, Xiaozhong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328565/
https://ncbi.nlm.nih.gov/pubmed/30631035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1242-1
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