Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the Hippo pathway

Neurofibromatosis type 1 (NF1) is a cancer predisposition disorder that results from inactivation of the tumor-suppressor Neurofibromin, a negative regulator of RAS signaling. NF1 patients present with a wide range of clinical manifestations and the tumor with highest prevalence is cutaneous neurofi...

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Publicado en:Cancer Discov
Autores principales: Chen, Zhiguo, Mo, Juan, Brosseau, Jean-Philippe, Shipman, Tracey, Wang, Yong, Liao, Chung-Ping, Cooper, Jonathan M., Allaway, Robert J., Gosline, Sara J.C., Guinney, Justin, Carroll, Thomas J., Le, Lu Q.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328325/
https://ncbi.nlm.nih.gov/pubmed/30348677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0151
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