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Cdk12 regulates DNA repair genes by suppressing intronic polyadenylation
Mutations that attenuate homologous recombination (HR) repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as “BRCAness.”(1) BRCAness tumors arise from loss-of-function mutations in 22 genes.(1) Of these genes, all but one (Cd...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6328294/ https://ncbi.nlm.nih.gov/pubmed/30487607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0758-y |
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