Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

The Cdk12/CycK complex promotes expression of a subset of RNA polymerase II genes, including those of the DNA damage response. CDK12 is among only nine genes with recurrent somatic mutations in high-grade serous ovarian carcinoma. However, the influence of these mutations on the Cdk12/CycK complex a...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Ekumi, Kingsley M., Paculova, Hana, Lenasi, Tina, Pospichalova, Vendula, Bösken, Christian A., Rybarikova, Jana, Bryja, Vitezslav, Geyer, Matthias, Blazek, Dalibor, Barboric, Matjaz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357706/
https://ncbi.nlm.nih.gov/pubmed/25712099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv101
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