The structure and substrate specificity of human Cdk12/Cyclin K

Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription. Here we determine the crystal structure of Cdk12/CycK and analyse its requirements for substrate recognition. Active Cdk12/CycK is arranged in an open conformation...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Bösken, Christian A., Farnung, Lucas, Hintermair, Corinna, Merzel Schachter, Miriam, Vogel-Bachmayr, Karin, Blazek, Dalibor, Anand, Kanchan, Fisher, Robert P., Eick, Dirk, Geyer, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973122/
https://ncbi.nlm.nih.gov/pubmed/24662513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4505
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker