The structure and substrate specificity of human Cdk12/Cyclin K

Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription. Here we determine the crystal structure of Cdk12/CycK and analyse its requirements for substrate recognition. Active Cdk12/CycK is arranged in an open conformation...

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Bibliographic Details
Main Authors: Bösken, Christian A., Farnung, Lucas, Hintermair, Corinna, Merzel Schachter, Miriam, Vogel-Bachmayr, Karin, Blazek, Dalibor, Anand, Kanchan, Fisher, Robert P., Eick, Dirk, Geyer, Matthias
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973122/
https://ncbi.nlm.nih.gov/pubmed/24662513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4505
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