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Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice
OBJECTIVE. Chronic pancreatitis is a progressive, relapsing inflammatory disorder of the pancreas, which often develops in the background of genetic susceptibility. Recently, loss-of-function mutations in CPA1, which encodes the digestive enzyme carboxypeptidase A1, were described in sporadic early-...
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| Publié dans: | Gut |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6326849/ https://ncbi.nlm.nih.gov/pubmed/30045879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-315994 |
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