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Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by...
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| Publicado no: | Dig Dis Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5487703/ https://ncbi.nlm.nih.gov/pubmed/28536777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-017-4601-3 |
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