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Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways

Diabetes-induced vascular endothelial dysfunction has been reported to involve hyperglycemia-induced increases in arginase activity. However, upstream mediators of this effect are not clear. Here, we have tested involvement of Rho kinase, ERK1/2 and p38 MAPK pathways in this process. Studies were pe...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Chandra, Surabhi, Fulton, David J. R., Caldwell, Ruth B., Caldwell, R. William, Toque, Haroldo A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326844/
https://ncbi.nlm.nih.gov/pubmed/30502342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2018.11.027
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