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Activated Rho Kinase Mediates Diabetes-Induced Elevation of Vascular Arginase Activation and Contributes to Impaired Corpora Cavernosa Relaxation: Possible Involvement of p38 MAPK Activation

INTRODUCTION: Activated RhoA/Rho kinase (ROCK) has been implicated in diabetes-induced erectile dysfunction. Earlier studies have demonstrated involvement of ROCK pathway in the activation of arginase in endothelial cells. However, signaling pathways activated by ROCK in the penis remain unclear. AI...

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Detalhes bibliográficos
Main Authors: Toque, Haroldo A., Nunes, Kenia P., Yao, Lin, Liao, James K., Webb, R. Clinton, Caldwell, Ruth B., Caldwell, R. William
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807104/
https://ncbi.nlm.nih.gov/pubmed/23566117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jsm.12134
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