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Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease

Cystic fibrosis (CF) and Wilson disease (WD) are two monogenetic, recessively inherited lethal pathologies that are caused by ionic disequilibria. CF results from loss-of-function mutations in CF transmembrane conductance regulator (CFTR), a channel that conducts chloride across epithelial cell memb...

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Bibliografski detalji
Izdano u:Aging (Albany NY)
Glavni autori: Maiuri, Luigi, Kroemer, Guido
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326686/
https://ncbi.nlm.nih.gov/pubmed/30568028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101736
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