Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Endoplasmic reticulum stress (ER stress) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease of progressive fibrosis and respiratory failure. ER stress activates a signaling pathway called the unfolded protein response (UPR) that either restores homeostasis or p...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C., Brumwell, Alexis, Chapman, Harold A., Backes, Bradley J., Perara, Gayani, Maly, Dustin J., Sheppard, Dean, Papa, Feroz R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326459/
https://ncbi.nlm.nih.gov/pubmed/30625178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209824
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