ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma

BACKGROUND: Increasing evidence support an important role for DNA methylation in nasopharyngeal carcinoma (NPC). Here, we explored the role of circadian clock gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) methylation in NPC. METHODS: We employed bisulfite pyrosequencing to determi...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Peng, Hao, Zhang, Jian, Zhang, Pan-Pan, Chen, Lei, Tang, Ling-Long, Yang, Xiao-Jing, He, Qing-Mei, Wen, Xin, Sun, Ying, Liu, Na, Li, Ying-Qin, Ma, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325889/
https://ncbi.nlm.nih.gov/pubmed/30621723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0997-7
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