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ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma

Abstract Background Increasing evidence support an important role for DNA methylation in nasopharyngeal carcinoma (NPC). Here, we explored the role of circadian clock gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) methylation in NPC. Methods We employed bisulfite pyrosequencing to...

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Main Authors: Hao Peng, Jian Zhang, Pan-Pan Zhang, Lei Chen, Ling-Long Tang, Xiao-Jing Yang, Qing-Mei He, Xin Wen, Ying Sun, Na Liu, Ying-Qin Li, Jun Ma
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Assuntos:
Nasopharyngeal carcinoma
ARNTL
Methylation
Proliferation
CDK5
Chemotherapy sensitivity
Acceso en liña:http://link.springer.com/article/10.1186/s13046-018-0997-7
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