Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma

Abstract Background Aberrant hypermethylation of cellular genes is a common phenomenon to inactivate genes and promote tumorigenesis in nasopharyngeal carcinoma (NPC). Methods Methyl binding domain (MBD)-ChIP sequencing of NPC cells, microarray data of NPC biopsies and gene ontology analysis were co...

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Main Authors: Hsin-Pai Li, Chen-Ching Peng, Chih-Ching Wu, Chien-Hsun Chen, Meng-Jhe Shih, Mei-Yuan Huang, Yi-Ru Lai, Yung-Li Chen, Ting-Wen Chen, Petrus Tang, Yu-Sun Chang, Kai-Ping Chang, Cheng-Lung Hsu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-05-01
Colecção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Nasopharyngeal carcinoma
Methylation
Tight junction
CLDN11
Acesso em linha:http://link.springer.com/article/10.1186/s13046-018-0754-y
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