Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), such as tuberous sclerosis complex (TSC). Treatment with the...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Brain
Main Authors: Kotajima-Murakami, Hiroko, Kobayashi, Toshiyuki, Kashii, Hirofumi, Sato, Atsushi, Hagino, Yoko, Tanaka, Miho, Nishito, Yasumasa, Takamatsu, Yukio, Uchino, Shigeo, Ikeda, Kazutaka
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325753/
https://ncbi.nlm.nih.gov/pubmed/30621732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-018-0423-2
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