Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), such as tuberous sclerosis complex (TSC). Treatment with the...

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Bibliografiske detaljer
Udgivet i:Mol Brain
Main Authors: Kotajima-Murakami, Hiroko, Kobayashi, Toshiyuki, Kashii, Hirofumi, Sato, Atsushi, Hagino, Yoko, Tanaka, Miho, Nishito, Yasumasa, Takamatsu, Yukio, Uchino, Shigeo, Ikeda, Kazutaka
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325753/
https://ncbi.nlm.nih.gov/pubmed/30621732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-018-0423-2
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