The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis

Treatments to stop gray matter degeneration are needed to prevent progressive disability in multiple sclerosis (MS). We tested whether inhibiting mixed-lineage kinases (MLKs), which can drive inflammatory microglial activation and neuronal degeneration, could protect hippocampal synapses in C57BL/6...

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Vydáno v:eNeuro
Hlavní autoři: Bellizzi, Matthew J., Hammond, Jennetta W., Li, Herman, Gantz Marker, Mary A., Marker, Daniel F., Freeman, Robert S., Gelbard, Harris A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2018
Témata:
New Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325567/
https://ncbi.nlm.nih.gov/pubmed/30627663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0245-18.2018
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