Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein

BACKGROUND AND PURPOSE: Disruption of nucleoporins has been reported in the motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS). However, the precise changes in the morphology of nucleoporins associated with the pathology of the 43-kDa TAR DNA-binding protein (TDP-43) in the...

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Publicado en:J Clin Neurol
Autores principales: Aizawa, Hitoshi, Yamashita, Takenari, Kato, Haruhisa, Kimura, Takashi, Kwak, Shin
Formato: Artigo
Lenguaje:Inglês
Publicado: Korean Neurological Association 2019
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325357/
https://ncbi.nlm.nih.gov/pubmed/30618218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3988/jcn.2019.15.1.62
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