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Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein

BACKGROUND AND PURPOSE: Disruption of nucleoporins has been reported in the motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS). However, the precise changes in the morphology of nucleoporins associated with the pathology of the 43-kDa TAR DNA-binding protein (TDP-43) in the...

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Detalhes bibliográficos
Publicado no:J Clin Neurol
Main Authors: Aizawa, Hitoshi, Yamashita, Takenari, Kato, Haruhisa, Kimura, Takashi, Kwak, Shin
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Neurological Association 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325357/
https://ncbi.nlm.nih.gov/pubmed/30618218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3988/jcn.2019.15.1.62
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