FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops

The 23-membered-ring macrolide tacrolimus, a commonly used immunosuppressant, also known as FK506, is a broad-spectrum inhibitor and an efflux pump substrate of pleiotropic drug resistance (PDR) ATP-binding cassette (ABC) transporters. Little, however, is known about the molecular mechanism by which...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Tanabe, Koichi, Bonus, Michele, Tomiyama, Susumu, Miyoshi, Kunji, Nagi, Minoru, Niimi, Kyoko, Chindamporn, Ariya, Gohlke, Holger, Schmitt, Lutz, Cannon, Richard D., Niimi, Masakazu, Lamping, Erwin
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325234/
https://ncbi.nlm.nih.gov/pubmed/30348662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01146-18
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