Single-Center Evaluation of the Pharmacokinetics of WCK 5222 (Cefepime-Zidebactam Combination) in Subjects with Renal Impairment

WCK 5222 is a novel β-lactam–β-lactam-enhancer combination of cefepime (FEP) and zidebactam (ZID). ZID is a novel β-lactam enhancer with a dual action of binding to Gram-negative penicillin-binding protein 2 (PBP2) and β-lactamase inhibition. WCK 5222 is being developed as a new therapeutic option f...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Preston, Richard A., Mamikonyan, Grigor, DeGraff, Stephane, Chiou, James, Kemper, Christopher J., Xu, Allan, Mastim, Mushtaque, Yeole, Ravindra, Chavan, Rajesh, Patel, Anasuya, Friedland, H. David, Bhatia, Ashima
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325229/
https://ncbi.nlm.nih.gov/pubmed/30397067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01484-18
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