Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata

Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in Candida mutational frequency of resistance or propensity to develop FKS mutations. The objective of this study was to measure spontaneous and FKS mutation rates among Candid...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Shields, Ryan K., Kline, Ellen G., Healey, Kelley R., Kordalewska, Milena, Perlin, David S., Nguyen, M. Hong, Clancy, Cornelius J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325211/
https://ncbi.nlm.nih.gov/pubmed/30373796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01692-18
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