Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal stability through increased integrin and dystroglycan attachment complexe...

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Publicat a:Nat Commun
Autors principals: Schips, Tobias G., Vanhoutte, Davy, Vo, Alexander, Correll, Robert N., Brody, Matthew J., Khalil, Hadi, Karch, Jason, Tjondrokoesoemo, Andoria, Sargent, Michelle A., Maillet, Marjorie, Ross, Robert S., Molkentin, Jeffery D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325143/
https://ncbi.nlm.nih.gov/pubmed/30622267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08026-8
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