Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

The extension of the amyloid hypothesis to include non-protein metabolite assemblies invokes a paradigm for the pathology of inborn error of metabolism disorders. However, a direct demonstration of the assembly of metabolite amyloid-like structures has so far been provided only in vitro. Here, we es...

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Udgivet i:Nat Commun
Main Authors: Laor, Dana, Sade, Dorin, Shaham-Niv, Shira, Zaguri, Dor, Gartner, Myra, Basavalingappa, Vasantha, Raveh, Avi, Pichinuk, Edward, Engel, Hamutal, Iwasaki, Keita, Yamamoto, Tatsuyuki, Noothalapati, Hemanth, Gazit, Ehud
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325136/
https://ncbi.nlm.nih.gov/pubmed/30622276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07966-5
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