A CD4(+) T cell population expanded in Lupus blood provides B cell help through IL10 and succinate

Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as Systemic Lupus Erythematosus (SLE)(1). Follicular helper T cells (Tfh) have long been implicated in SLE pathogenesis. Yet, a fraction of SLE patients’ aut...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Caielli, Simone, Troggian Veiga, Diogo, Balasubramanian, Preetha, Athale, Shruti, Domic, Bojana, Murat, Elise, Banchereau, Romain, Xu, Zhaohui, Chandra, Manjari, Chung, Cheng-Han, Walters, Lynnette, Baisch, Jeanine, Wright, Tracey, Punaro, Marilynn, Nassi, Lorien, Stewart, Katie, Fuller, Julie, Ucar, Duygu, Ueno, Hideki, Zhou, Joseph, Banchereau, Jacques, Pascual, Virginia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325012/
https://ncbi.nlm.nih.gov/pubmed/30478422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0254-9
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