Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils exposed to TLR7 agonist autoantibodies release interferogenic DNA, which we now demonstrate to be of mitochondrial origin....

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Caielli, Simone, Athale, Shruti, Domic, Bojana, Murat, Elise, Chandra, Manjari, Banchereau, Romain, Baisch, Jeanine, Phelps, Kate, Clayton, Sandra, Gong, Mei, Wright, Tracey, Punaro, Marilynn, Palucka, Karolina, Guiducci, Cristiana, Banchereau, Jacques, Pascual, Virginia
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854735/
https://ncbi.nlm.nih.gov/pubmed/27091841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151876
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