Φορτώνει......
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus
Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils exposed to TLR7 agonist autoantibodies release interferogenic DNA, which we now demonstrate to be of mitochondrial origin....
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Exp Med |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Rockefeller University Press
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854735/ https://ncbi.nlm.nih.gov/pubmed/27091841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151876 |
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