Stem cells repurpose proliferation to contain a breach in their niche barrier

Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt barrier function, adjacent stem cells dramatically...

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Udgivet i:eLife
Main Authors: Lay, Kenneth, Yuan, Shaopeng, Gur-Cohen, Shiri, Miao, Yuxuan, Han, Tianxiao, Naik, Shruti, Pasolli, H Amalia, Larsen, Samantha B, Fuchs, Elaine
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Stem Cells and Regenerative Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324878/
https://ncbi.nlm.nih.gov/pubmed/30520726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41661
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